Hormone Synthesis, My Recovery and How You Benefit
Cholesterol metabolizes to pregnenolone, then to progesterone
that progresses to androstenedione, which metabolizes to
testosterone and goes to estrogen.
With this basic knowledge of how hormones are made in the body, I
decided to measure mine in a salivary test, which I learned is
more accurate than a blood test. I had the testosterone level of
a 90-year-old man and the estrogen level of a 21-year-old
female! No wonder I liked purses, shoes, and shopping at
Victoria’s Secret and cried during movies; I had the hormones of
a woman. Men should have 50 times more testosterone than
estrogen!
Now I asked the obvious questions: “Why? And how do you convert
testosterone to estrogen?” I found there is an enzyme called
aromatase that converts male to female hormones. If everything
is functioning normally, there is a normal ratio of male to
female hormones or testosterone to estrogen. It was obvious mine
wasn’t functioning properly.
I also started to research the question, “Why is that enzyme
overacting and converting my testosterone to estrogen?” I
learned that aging; lack of zinc and vitamin C; excess leptin, a
fat cell hormone; low thyroid; excess insulin and testosterone;
inflammation; and abnormal cortisol increased the aromatase
enzyme.
Next, I had to study nutritional biochemistry, thyroid, insulin,
cortisol, inflammation and leptin metabolism to determine my
values. This is complex biochemistry and most physicians won’t
take the time to do this level of research.
Upon the correction of all the factors contributing to conversion
of testosterone to estrogen, I lost 40 pounds and all my
symptoms resolved in three months.
This was a life-changing experience for me and my patients. It
changed the way I practice medicine. I became more empathetic, a
better listener and a more extensive researcher as I continued
to study at least six to ten hours a day.
Looking back, I’m glad this happened to me. It made me realize
that my patient evaluation in the past was completely
inadequate. What happened to me made me a better physician all
around.
In the past, I could only resolve symptoms with a prescription
medication or surgical procedure. I now resolve them by first
asking what is causing my patients’ symptoms. Once I determine
the root cause of the problem through extensive testing and
counseling, action can be taken through lifestyle changes,
nutritional supplementation and the appropriate medication, if
indicated.
There are millions of reactions that occur in our body every
second and many factors affect those reactions, including
thoughts, diet, sleep pattern, stress, exercise, environment,
genetics, and medication. When all those reactions are
functioning properly, we experience overall wellness and a sense
of wellbeing. When those reactions become abnormal or
dysfunctional, as in my case, symptoms leading to disability,
disease, premature aging or premature death will develop. You
want to determine the root cause of the problem, not mask the
symptoms with a medication!